Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845524 | 1.00 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL3709010 | 0.88 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL3709009 | 0.88 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL1844871 | 0.80 | TAAR1 (0.38) | PTGDR2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL3717915 | 0.77 | KMT2A (0.34) | KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL958964 | 0.77 | KMT2A (0.36) | KMT2AMEN1ALOX5ALDH1A1CHRM2 | |
| SCHEMBL3709505 | 0.77 | THRA (0.46) | HDAC1HDAC6PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL9955949 | 0.76 | MEN1 (0.38) | HDAC1HDAC6PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL1846498 | 0.73 | TAAR1 (0.37) | HDAC1HDAC6PTGDR2KMT2AMEN1 | |
| SCHEMBL735527 | 0.70 | SMN1; SMN2 (0.34) | KMT2AMEN1ALOX5ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324017-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010157-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |