Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709505 | 0.88 | THRA (0.46) | THRATHRBKMT2ANPC1RAB9A | |
| SCHEMBL1847562 | 0.78 | KMT2A (0.46) | THRATHRBKMT2ANPC1RAB9A | |
| SCHEMBL659686 | 0.76 | PDPK1 (0.64) | KMT2ANPC1RAB9ACASP3SENP8 | |
| SCHEMBL2209750 | 0.76 | CCR6 (0.50) | KMT2ANPC1RAB9ATDP1MEN1 | |
| SCHEMBL1869067 | 0.74 | UTS2R (0.46) | KMT2AMEN1MAPTL3MBTL1HPGD | |
| SCHEMBL1869071 | 0.74 | UTS2R (0.46) | KMT2AMEN1MAPTL3MBTL1HPGD | |
| SCHEMBL957332 | 0.74 | UTS2R (0.46) | KMT2AMEN1MAPTL3MBTL1HPGD | |
| SCHEMBL2211472 | 0.72 | CCR6 (0.46) | KMT2ANPC1RAB9ATDP1MEN1 | |
| SCHEMBL3646047 | 0.72 | KMT2A (0.43) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL8145760 | 0.72 | NPC1 (0.58) | KMT2ANPC1RAB9ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324017-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010157-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |