Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536135 | 0.88 | MEN1 (0.51) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL19583110 | 0.87 | MEN1 (0.46) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL19583111 | 0.87 | MEN1 (0.46) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL13902931 | 0.87 | MEN1 (0.46) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL2991006 | 0.87 | MEN1 (0.46) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL19734564 | 0.86 | KMT2A (0.45) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL1934571 | 0.84 | MEN1 (0.54) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL12282446 | 0.84 | MEN1 (0.54) | MEN1KMT2ADPP8DPP7YTHDC1 | |
| SCHEMBL2994780 | 0.83 | KMT2A (0.46) | MEN1KMT2ADPP8DPP7MAOA | |
| SCHEMBL2994779 | 0.83 | KMT2A (0.46) | MEN1KMT2ADPP8DPP7MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091438-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
| CN-110709402-B | Heteroaryl pyrimidone derivatives, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-110709402-A | Heteroaryl pyrimidone derivatives, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-109988120-A | A kind of indoles amine -2,3- dioxygenase inhibitor and its preparation method and application | 成都海创药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| EP-2209771-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | Pfizer, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009060278-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | PFIZER INC. (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | TCOF1, SLC10A2, PAM | MEN1 77/4885KMT2A 2833/4885DPP8 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.