Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709686 | 1.00 | NPC1 (0.37) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL2775907 | 0.93 | RAB9A (0.41) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL2775911 | 0.93 | RAB9A (0.41) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL3070004 | 0.75 | CES2 (0.43) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL2776826 | 0.75 | CES2 (0.43) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL2776829 | 0.75 | CES2 (0.43) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL3711794 | 0.73 | ALDH1A1 (0.48) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL3711791 | 0.73 | ALDH1A1 (0.48) | NPC1RAB9ATDP1KMT2AMAPT | |
| SCHEMBL2777213 | 0.72 | ALDH1A1 (0.48) | NPC1KMT2AMAPTTSHRSMN1; SMN2 | |
| SCHEMBL2777208 | 0.72 | ALDH1A1 (0.48) | NPC1KMT2AMAPTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |