Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | HBB | P68871 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209850 | 0.79 | KDM4E (0.52) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL10181440 | 0.76 | THRB (0.45) | THRBSCN9ASCN7AKCNH2SCN5A | |
| SCHEMBL7835979 | 0.74 | PRKCI (0.50) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL539086 | 0.71 | ALDH1A1 (0.45) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL20931746 | 0.70 | KDM4E (0.79) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL3702189 | 0.70 | HSPB1 (0.52) | RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5342115 | 0.70 | KDM4E (0.62) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL3708088 | 0.69 | KDM4E (0.50) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL6210172 | 0.68 | KDM4E (0.59) | KDM4EPOLBMEN1KMT2A | |
| SCHEMBL8736385 | 0.68 | KDM4E (0.69) | KDM4EPOLBRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207773-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009057811-A2 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-05-07 | — | — | WO | disclosed |