Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 2/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188885 | 0.88 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2KDM4EHSD17B10 | |
| SCHEMBL3713704 | 0.88 | CYP19A1 (0.39) | CYP19A1CYP11B1CYP11B2CSF1RGRM5 | |
| SCHEMBL3711486 | 0.88 | CYP19A1 (0.39) | CYP19A1CYP11B1CYP11B2CSF1RGRM5 | |
| SCHEMBL3711602 | 0.86 | TACR3 (0.41) | MAPK1FFAR1XIAPBIRC2 | |
| SCHEMBL3712399 | 0.84 | GRM5 (0.46) | CYP19A1CYP11B1CYP11B2GRM5ALDH1A1 | |
| SCHEMBL3714356 | 0.84 | NAMPT (0.41) | CYP19A1CYP11B1CYP11B2CSF1RGRM5 | |
| SCHEMBL3710834 | 0.83 | KDM4E (0.45) | CYP19A1CYP11B1CYP11B2CSF1RKDM4E | |
| SCHEMBL3711552 | 0.83 | ALDH1A1 (0.46) | CYP19A1CYP11B1CYP11B2CSF1RKDM4E | |
| SCHEMBL3710434 | 0.82 | KMT2A (0.43) | CYP19A1CYP11B1CYP11B2CSF1RKDM4E | |
| SCHEMBL3712323 | 0.82 | CYP19A1 (0.46) | CYP19A1CYP11B1CYP11B2CSF1RGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |