Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711236 | 0.88 | HDAC6 (0.36) | SLC6A2SLC6A4SLC6A3HDAC6USP2 | |
| SCHEMBL3709501 | 0.87 | HTR2C (0.42) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL3716651 | 0.83 | HDAC6 (0.39) | SLC6A2SLC6A4SLC6A3HDAC6USP2 | |
| SCHEMBL3716482 | 0.82 | HTR2A (0.43) | SLC6A2SLC6A4HDAC6HDAC4HDAC3 | |
| SCHEMBL3712760 | 0.78 | SLC6A3 (0.41) | SLC6A2SLC6A4SLC6A3HDAC6HDAC3 | |
| SCHEMBL3712314 | 0.78 | SLC6A3 (0.46) | SLC6A2SLC6A4SLC6A3HDAC6HDAC3 | |
| SCHEMBL3705259 | 0.77 | CTSD (0.37) | SLC6A2SLC6A4SLC6A3HDAC6USP2 | |
| SCHEMBL3705030 | 0.77 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3HDAC6USP2 | |
| SCHEMBL3709523 | 0.75 | HDAC3 (0.39) | SLC6A2SLC6A4SLC6A3HDAC6HDAC3 | |
| SCHEMBL28305231 | 0.75 | PSEN1 (0.36) | SLC6A4SLC6A3PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |