Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 3/20 | 0.42 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711204 | 0.88 | TP53 (0.55) | TP53NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL3715992 | 0.87 | MAPK1 (0.43) | LMNARAB9ASMN1; SMN2ACP1MOK | |
| SCHEMBL3709357 | 0.86 | ACP1 (0.53) | SMN1; SMN2ACP1MOKALKKDM4E | |
| SCHEMBL3711316 | 0.85 | ALK (0.40) | ALK | |
| SCHEMBL3712000 | 0.85 | MAPK1 (0.36) | ACP1ALK | |
| SCHEMBL3710995 | 0.84 | L3MBTL1 (0.39) | LMNARAB9ASMN1; SMN2ACP1MOK | |
| SCHEMBL3721238 | 0.84 | EPHX2 (0.42) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL3716971 | 0.83 | ACP1 (0.39) | ACP1ALK | |
| SCHEMBL3715458 | 0.82 | L3MBTL1 (0.37) | LMNARAB9ASMN1; SMN2ALKMAPT | |
| SCHEMBL13188445 | 0.80 | HRH3 (0.41) | LMNARAB9ASMN1; SMN2ACP1MOK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |