Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710995 | 0.92 | L3MBTL1 (0.39) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL3711316 | 0.91 | ALK (0.40) | L3MBTL1 | |
| SCHEMBL3715458 | 0.91 | L3MBTL1 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL3721238 | 0.89 | EPHX2 (0.42) | L3MBTL1AURKAAURKBRAB9ASMN1; SMN2 | |
| SCHEMBL3709976 | 0.87 | TP53 (0.49) | ACP1MOKLMNAMAPTTSHR | |
| SCHEMBL3712000 | 0.87 | MAPK1 (0.36) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL3714015 | 0.86 | JAK2 (0.44) | JAK2JAK3 | |
| SCHEMBL3709357 | 0.86 | ACP1 (0.53) | ACP1MOKTSHRSMN1; SMN2 | |
| SCHEMBL13188445 | 0.85 | HRH3 (0.41) | MAPK1L3MBTL1ACP1MOKLMNA | |
| SCHEMBL3709302 | 0.85 | BCHE (0.44) | L3MBTL1JAK2ACP1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |