Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371061 | 0.74 | MET (0.44) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL361252 | 0.72 | MET (0.43) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL371227 | 0.70 | MET (0.43) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL13506534 | 0.70 | FGFR2 (0.37) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL10283506 | 0.65 | ALDH1A1 (0.52) | METALDH1A1F2GLAHPGD | |
| SCHEMBL19514121 | 0.65 | ALDH1A1 (0.51) | METALDH1A1F2GLAHPGD | |
| SCHEMBL371056 | 0.64 | PDE10A (0.41) | FGFR3FGFR1FGFR2FGFR4KDR | |
| SCHEMBL10283429 | 0.64 | MET (0.44) | MET | |
| SCHEMBL359990 | 0.64 | MET (0.37) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL20616575 | 0.64 | ALDH1A1 (0.54) | METALDH1A1F2GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |