Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 7/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 3/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361506 | 0.70 | PDE10A (0.42) | PDE10AMIFFGFR1FGFR2FGFR4 | |
| SCHEMBL371227 | 0.67 | MET (0.43) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL371060 | 0.64 | MET (0.44) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL2365324 | 0.64 | IRAK1 (0.34) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL2365270 | 0.64 | IRAK4 (0.38) | — | |
| SCHEMBL9694076 | 0.62 | KDM4E (0.54) | NCF1 | |
| SCHEMBL19066027 | 0.60 | CYP1A2 (0.50) | PDE10AMAOBNCF1 | |
| SCHEMBL21704647 | 0.59 | SLC6A2 (0.49) | PDE10AKCNH2 | |
| SCHEMBL19066016 | 0.59 | MAPT (0.58) | MAOBNCF1 | |
| SCHEMBL255618 | 0.58 | PDE10A (0.38) | PDE10AFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | claimed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | claimed |