Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717915 | 0.89 | KMT2A (0.34) | SMN1; SMN2ALDH1A1KMT2AL3MBTL1TDP1 | |
| SCHEMBL3646232 | 0.89 | BCL2 (0.39) | BCL2HTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3646047 | 0.80 | KMT2A (0.43) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1846565 | 0.79 | ALDH1A1 (0.34) | ALDH1A1KMT2AL3MBTL1TDP1KCNN4 | |
| SCHEMBL958265 | 0.77 | UTS2R (0.39) | BCL2KMT2AL3MBTL1MEN1 | |
| SCHEMBL1844871 | 0.71 | TAAR1 (0.38) | KCNN4 | |
| SCHEMBL24451337 | 0.69 | KCNN4 (0.49) | HTTSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL3645623 | 0.69 | KMT2A (0.43) | SMN1; SMN2ALDH1A1KMT2AMEN1CYP1A2 | |
| SCHEMBL15949367 | 0.69 | UTS2R (0.39) | BCL2 | |
| SCHEMBL2546997 | 0.68 | ALDH1A1 (0.40) | HTTSMN1; SMN2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393807-A1 | CYCLIC INHIBITORS OF 11 -HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089303-A1 | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-12 | — | — | WO | disclosed |