Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845524 | 0.80 | HDAC1 (0.39) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL1845523 | 0.80 | HDAC1 (0.39) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL1846498 | 0.75 | TAAR1 (0.37) | TAAR1KCNN4KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL3710698 | 0.71 | BCL2 (0.39) | KCNN4 | |
| SCHEMBL958265 | 0.71 | UTS2R (0.39) | — | |
| SCHEMBL24451337 | 0.70 | KCNN4 (0.49) | HIF1AKCNN4 | |
| SCHEMBL3709009 | 0.69 | HDAC1 (0.39) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL3709010 | 0.69 | HDAC1 (0.39) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL18801994 | 0.67 | PLAAT3 (0.49) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5348780 | 0.67 | TAAR1 (0.50) | TAAR1PLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324017-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010157-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |