Sugi Predict

Sugi Predict / Compounds / SCHEMBL3711099

SCHEMBL3711099

SCHEMBL3711099

CC(=O)C1=C(O)C(=O)N(CCc2ccc3c(c2)OCO3)C1c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP7 Q93009 1/20 0.60
▸ TSHR P16473 2/20 0.56
▸ KDM4E B2RXH2 7/20 0.55
▸ ALDH1A1 P00352 7/20 0.55
▸ SMN1; SMN2 Q16637 3/20 0.55
▸ MAPT P10636 3/20 0.55
▸ USP2 O75604 1/20 0.55
▸ ALOX15 P16050 1/20 0.55
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ HTT P42858 2/20 0.45
▸ PKM P14618 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.44
▸ CCR1 P32246 1/20 0.44
▸ CCR2 P41597 1/20 0.44
▸ HPGD P15428 3/20 0.44
▸ RXFP1 Q9HBX9 3/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ PPARG P37231 1/20 0.43
▸ NCOR2 Q9Y618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3709177 0.86 USP7 (0.57) USP7TSHRKDM4EALDH1A1SMN1; SMN2
SCHEMBL3711000 0.85 TSHR (0.71) USP7TSHRKDM4EALDH1A1SMN1; SMN2
SCHEMBL3702953 0.84 ALDH1A1 (0.64) USP7TSHRKDM4EALDH1A1SMN1; SMN2
SCHEMBL3703776 0.83 SMN1; SMN2 (0.64) USP7TSHRKDM4EALDH1A1SMN1; SMN2
SCHEMBL3716480 0.80 USP7 (0.78) USP7TSHRKDM4EALDH1A1MAPT
SCHEMBL3707178 0.80 USP7 (0.78) USP7TSHRKDM4EALDH1A1MAPT
SCHEMBL3709046 0.80 USP7 (0.78) USP7TSHRKDM4EALDH1A1MAPT
SCHEMBL3715636 0.76 ALDH1A1 (0.61) KDM4EALDH1A1SMN1; SMN2MAPTUSP2
SCHEMBL16904823 0.75 USP7 (0.61) USP7TSHRKDM4EALDH1A1SMN1; SMN2
SCHEMBL3705385 0.73 USP7 (0.79) USP7TSHRKDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO claimed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP claimed
US-20220125760-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) 2022-04-28 — — US disclosed
EP-3923987-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2021-12-22 — — EP disclosed
WO-2020165315-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2020-08-20 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed