Sugi Predict

Sugi Predict / Compounds / SCHEMBL3702953

SCHEMBL3702953

SCHEMBL3702953

CC(=O)C1=C(O)C(=O)N(CCc2ccccc2)C1c1ccc2c(c1)OCO2

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.64
▸ ALOX15 P16050 6/20 0.64
▸ MAPT P10636 3/20 0.64
▸ USP2 O75604 2/20 0.64
▸ SMN1; SMN2 Q16637 1/20 0.64
▸ KDM4E B2RXH2 6/20 0.56
▸ LMNA P02545 1/20 0.54
▸ FPR1 P21462 3/20 0.53
▸ POLB P06746 1/20 0.52
▸ GAA P10253 4/20 0.52
▸ HSD17B10 Q99714 2/20 0.52
▸ HPGD P15428 1/20 0.51
▸ HTT P42858 2/20 0.51
▸ TSHR P16473 1/20 0.51
▸ CYP2C9 P11712 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ RXFP1 Q9HBX9 2/20 0.49
▸ PPARG P37231 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3715636 0.91 ALDH1A1 (0.61) ALDH1A1ALOX15MAPTUSP2SMN1; SMN2
SCHEMBL3703776 0.84 SMN1; SMN2 (0.64) ALDH1A1ALOX15MAPTUSP2SMN1; SMN2
SCHEMBL3711099 0.84 USP7 (0.60) ALDH1A1ALOX15MAPTUSP2SMN1; SMN2
SCHEMBL3707111 0.83 SMN1; SMN2 (0.55) ALDH1A1ALOX15MAPTUSP2SMN1; SMN2
SCHEMBL3706130 0.81 ALOX15 (0.62) ALDH1A1ALOX15MAPTKDM4ELMNA
SCHEMBL3705035 0.81 KDM4E (0.66) ALDH1A1ALOX15MAPTSMN1; SMN2KDM4E
SCHEMBL3706706 0.81 MEN1 (0.60) ALDH1A1ALOX15MAPTUSP2SMN1; SMN2
SCHEMBL3716653 0.81 USP7 (0.70) ALDH1A1ALOX15USP2SMN1; SMN2KDM4E
SCHEMBL16904821 0.80 KDM4E (0.64) ALDH1A1ALOX15MAPTKDM4ELMNA
SCHEMBL3707576 0.80 KDM4E (0.64) ALDH1A1ALOX15MAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO claimed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP claimed
US-20220125760-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) 2022-04-28 — — US disclosed
EP-3923987-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2021-12-22 — — EP disclosed
WO-2020165315-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2020-08-20 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
WO-2010081783-A1 NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS HYBRIGENICS SA (FR) 2010-07-22 — — WO disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed
EP-2208725-A1 Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications Hybrigenics S.A. (FR) 2010-07-21 — — EP disclosed