Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713838 | 0.86 | GRIN2D (0.43) | HSD17B10KDM4EALDH1A1CYP1A2GRIN2D | |
| SCHEMBL3716515 | 0.85 | KDM4E (0.40) | HSD17B10KDM4EALDH1A1CYP1A2TSHR | |
| SCHEMBL3710764 | 0.77 | PTGDR2 (0.47) | HSD17B10KDM4EALDH1A1CYP1A2GRIN2D | |
| SCHEMBL4067945 | 0.75 | HSD17B10 (0.61) | HSD17B10KDM4EALDH1A1CYP1A2GRIN2D | |
| SCHEMBL31146173 | 0.74 | DAO (0.58) | HSD17B10KDM4EALDH1A1GRIN2DGRIN3B | |
| SCHEMBL4064969 | 0.74 | HSD17B10 (0.46) | HSD17B10KDM4EALDH1A1CYP1A2GRIN2D | |
| SCHEMBL3714878 | 0.71 | KDM4E (0.46) | HSD17B10KDM4EALDH1A1CYP1A2TSHR | |
| SCHEMBL3711402 | 0.71 | KDM4E (0.55) | HSD17B10KDM4EALDH1A1TSHRHPGD | |
| SCHEMBL3713030 | 0.71 | PDE2A (0.40) | KDM4EALDH1A1TSHRMAPTGRIK1 | |
| SCHEMBL463637 | 0.70 | GRIA1 (0.54) | HSD17B10KDM4EALDH1A1CYP1A2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393806-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | Elan Pharmaceuticals Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091310-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |