Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711310 | 0.85 | HSD17B10 (0.38) | KDM4EHSD17B10ALDH1A1CYP1A2TSHR | |
| SCHEMBL3713030 | 0.77 | PDE2A (0.40) | KDM4EALDH1A1TSHRMAPTKMT2A | |
| SCHEMBL3715319 | 0.76 | EGFR (0.44) | KDM4EHSD17B10ALDH1A1HPGDKMT2A | |
| SCHEMBL3718863 | 0.75 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL3712923 | 0.75 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1CYP1A2TSHR | |
| SCHEMBL31423008 | 0.73 | GRIK1 (0.41) | KDM4EALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL7071513 | 0.73 | IDH1 (0.51) | KDM4EHSD17B10ALDH1A1CYP1A2TSHR | |
| SCHEMBL8306652 | 0.72 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL3719191 | 0.72 | IDH1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL7073150 | 0.72 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393806-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | Elan Pharmaceuticals Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091310-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |