Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067945 | 0.82 | HSD17B10 (0.61) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3713838 | 0.81 | GRIN2D (0.43) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9270023 | 0.78 | SIRT1 (0.47) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5678790 | 0.75 | MAPK1 (0.61) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30434363 | 0.75 | MAPK1 (0.61) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31146173 | 0.75 | DAO (0.58) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3713356 | 0.75 | GRIN2D (0.44) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14128774 | 0.75 | GRIA1 (0.53) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4066152 | 0.74 | ALDH1A1 (0.44) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3711310 | 0.74 | HSD17B10 (0.38) | HSD17B10GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |