Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352669 | 0.82 | HSD17B10 (0.63) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL4064969 | 0.82 | HSD17B10 (0.46) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL3713838 | 0.82 | GRIN2D (0.43) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL30434363 | 0.77 | MAPK1 (0.61) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL5678790 | 0.77 | MAPK1 (0.61) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL3713356 | 0.76 | GRIN2D (0.44) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL31146173 | 0.76 | DAO (0.58) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL4659631 | 0.76 | KDM4E (0.61) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL22639675 | 0.76 | HSD17B10 (1.00) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL8828077 | 0.76 | KDM4E (0.58) | HSD17B10KDM4EALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |