Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 2/20 | 0.34 |
| ▸ | SI | P14410 | 2/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390326 | 0.87 | GPBAR1 (0.52) | GAAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL362520 | 0.80 | GPBAR1 (0.46) | GAAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1390427 | 0.79 | GPBAR1 (0.41) | GAAKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL6289274 | 0.78 | SMN1; SMN2 (0.54) | GAAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL370198 | 0.77 | WNT3A (0.40) | GAAGPBAR1POLBMGAMSI | |
| SCHEMBL370012 | 0.77 | GPBAR1 (0.57) | GAASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL1390267 | 0.75 | GPBAR1 (0.48) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL371090 | 0.74 | KDM4E (0.44) | KMT2AALDH1A1MAPTKDM4EGPBAR1 | |
| SCHEMBL17466005 | 0.74 | MEN1 (0.58) | GAAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL370156 | 0.73 | FFAR1 (0.45) | KMT2AGPBAR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |