Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 3/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360971 | 0.87 | TBXAS1 (0.41) | RAB9AAXLMERTKUBE2NRIPK2 | |
| SCHEMBL12503516 | 0.84 | DGAT1 (0.39) | RAB9AUBE2NMAPK1DGAT1PRMT5 | |
| SCHEMBL360085 | 0.83 | PARP10 (0.43) | — | |
| SCHEMBL360220 | 0.81 | TBXAS1 (0.41) | RAB9AMAPK1L3MBTL1HRH3 | |
| SCHEMBL14930551 | 0.80 | ALDH1A1 (0.38) | RAB9AL3MBTL1HRH3 | |
| SCHEMBL12503425 | 0.79 | MEN1 (0.40) | RAB9AMAPTL3MBTL1 | |
| SCHEMBL359456 | 0.79 | FGFR1 (0.36) | RAB9AAXLMERTKPRMT5MAPT | |
| SCHEMBL10283805 | 0.77 | NPC1 (0.32) | RAB9APRMT5L3MBTL1 | |
| SCHEMBL14926941 | 0.76 | MAPT (0.42) | RAB9AAXLMAPK1MAPT | |
| SCHEMBL359734 | 0.76 | IRAK1 (0.38) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |