Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249148 | 0.84 | MGLL (0.41) | SIGMAR1 | |
| SCHEMBL31132514 | 0.82 | TSHR (0.36) | SIGMAR1MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL27678060 | 0.79 | SIGMAR1 (0.51) | SIGMAR1MAPK1MEN1KMT2AUSP2 | |
| SCHEMBL6012279 | 0.79 | SIGMAR1 (0.55) | SIGMAR1USP2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL31132746 | 0.79 | KMT2A (0.41) | KMT2AALDH1A1HPGD | |
| SCHEMBL27696613 | 0.78 | SIGMAR1 (0.50) | SIGMAR1MAPK1MEN1KMT2AUSP2 | |
| SCHEMBL27626264 | 0.76 | SIGMAR1 (0.44) | SIGMAR1MAPK1MEN1KMT2AUSP2 | |
| SCHEMBL4107014 | 0.76 | MAPK1 (0.57) | SIGMAR1MAPK1MEN1KMT2AUSP2 | |
| SCHEMBL1502938 | 0.76 | SOS1 (0.31) | — | |
| SCHEMBL15034009 | 0.76 | HPGD (0.36) | SIGMAR1USP2ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |