SCHEMBL3712368

SCHEMBL3712368

COC(=O)CCc1ncc(C(C)(C)C)o1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 13/20 0.42
CCNE2 O96020 11/20 0.42
CCNE1 P24864 11/20 0.42
CCNB2 O95067 5/20 0.42
CDK1 P06493 5/20 0.42
CCNB1 P14635 5/20 0.42
CCNB3 Q8WWL7 5/20 0.42
CDK4 P11802 5/20 0.42
CCND1 P24385 5/20 0.42
CCND3 P30281 4/20 0.42
CCND2 P30279 1/20 0.42
HDAC3 O15379 5/20 0.40
HDAC4 P56524 5/20 0.40
HDAC1 Q13547 5/20 0.40
HDAC7 Q8WUI4 5/20 0.40
HDAC2 Q92769 5/20 0.40
HDAC10 Q969S8 5/20 0.40
HDAC11 Q96DB2 5/20 0.40
HDAC8 Q9BY41 5/20 0.40
HDAC6 Q9UBN7 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13189035 0.91 HDAC1 (0.42) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL3719448 0.82 RXRA (0.51) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL124533 0.77 KDM4E (0.39) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3715500 0.77 CYP1A2 (0.39) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL3718311 0.76 RXRA (0.42) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL13616184 0.75 CDK2 (0.48) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL27811865 0.72 TSHR (0.40) RPS6KB2
SCHEMBL14146107 0.72 CCNB2 (0.37) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL13188146 0.71 CDK2 (0.41) CDK2CCNE2CCNE1CCNB2CDK1
SCHEMBL22352802 0.71 HDAC1 (0.45) CDK2CCNE2CCNE1CDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010100144-A1 FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE MERCK SERONO S.A. (CH) 2010-09-10 WO disclosed
WO-2010100144-A1 FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE MERCK SERONO S.A. (CH) 2010-09-10 WO disclosed