Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188286 | 0.92 | ALDH1A1 (0.51) | ALDH1A1ERN1ARKDM4EMAPT | |
| SCHEMBL3713984 | 0.90 | ACACB (0.58) | ACACBALDH1A1ARKDM4ENPC1 | |
| SCHEMBL3709550 | 0.80 | KDM4E (0.52) | ALDH1A1ERN1KDM4ENPC1RAB9A | |
| SCHEMBL3711202 | 0.80 | ACACB (0.46) | ACACBALDH1A1ERN1NR4A2FFAR1 | |
| SCHEMBL17435488 | 0.80 | GLRA3 (0.47) | ACACBALDH1A1ARKDM4EMAPT | |
| SCHEMBL3711934 | 0.79 | ACACB (0.53) | ACACBALDH1A1ARFFAR1 | |
| SCHEMBL3711389 | 0.79 | ACACB (0.58) | ACACBALDH1A1KDM4EFFAR1 | |
| SCHEMBL30800091 | 0.78 | ALDH1A1 (0.54) | ACACBALDH1A1ARKDM4EMAPT | |
| SCHEMBL15530701 | 0.77 | MMP2 (0.44) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL6611571 | 0.77 | ALDH1A1 (0.49) | ACACBALDH1A1ARKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |