Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713216 | 0.87 | ACACB (0.52) | ACACBFFAR1ALDH1A1AAK1GRM5 | |
| SCHEMBL3716655 | 0.84 | FFAR1 (0.45) | FFAR1GRM5 | |
| SCHEMBL3712320 | 0.82 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2ALDH1A1SLC2A1 | |
| SCHEMBL3714187 | 0.81 | ALDH1A1 (0.51) | CYP19A1CYP11B1CYP11B2FFAR1ALDH1A1 | |
| SCHEMBL3710033 | 0.81 | ALDH1A1 (0.54) | CYP19A1CYP11B1CYP11B2FFAR1ALDH1A1 | |
| SCHEMBL3711387 | 0.80 | AAK1 (0.45) | CYP19A1CYP11B1CYP11B2FFAR1ALDH1A1 | |
| SCHEMBL3712463 | 0.80 | ACACB (0.47) | ACACBFFAR1ALDH1A1ERN1NR4A2 | |
| SCHEMBL3711389 | 0.80 | ACACB (0.58) | ACACBFFAR1ALDH1A1PORCN | |
| SCHEMBL3713933 | 0.80 | SCN9A (0.44) | CYP19A1CYP11B1CYP11B2FFAR1ALDH1A1 | |
| SCHEMBL3717587 | 0.79 | AAK1 (0.42) | CYP19A1CYP11B1CYP11B2FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |