Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579300 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNA | |
| SCHEMBL3857572 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL3720398 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4ECDC7ROCK2PIM1 | |
| SCHEMBL3715004 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL3350040 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL3711270 | 0.75 | PIK3CA (0.61) | ALDH1A1KDM4EGSK3BHPGDCRHBP | |
| SCHEMBL30931811 | 0.74 | LMNA (0.59) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL730969 | 0.74 | LMNA (0.59) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL20225508 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL1424831 | 0.74 | KDM4E (0.47) | SMN1; SMN2ALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |