Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722239 | 0.87 | ULK1 (0.50) | EGFRSMN1; SMN2BTKITKJAK3 | |
| SCHEMBL3714738 | 0.83 | EGFR (0.53) | EGFRSYKBTKITKJAK3 | |
| SCHEMBL913703 | 0.81 | STAT6 (0.59) | EGFRSYKJAK3 | |
| SCHEMBL914128 | 0.81 | STAT6 (0.59) | EGFRSYKJAK3 | |
| SCHEMBL913701 | 0.81 | STAT6 (0.59) | EGFRSYKJAK3 | |
| SCHEMBL3715974 | 0.80 | JAK3 (0.55) | EGFRSYKJAK3ULK1PDK1 | |
| SCHEMBL3712505 | 0.80 | JAK3 (0.55) | EGFRSYKJAK3ULK1PDK1 | |
| SCHEMBL912973 | 0.79 | SYK (0.55) | EGFRALDH1A1HPGDTSHRSYK | |
| SCHEMBL912974 | 0.79 | SYK (0.55) | EGFRALDH1A1HPGDTSHRSYK | |
| SCHEMBL912976 | 0.79 | SYK (0.55) | EGFRALDH1A1HPGDTSHRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |