Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.50 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 3/20 | 0.45 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803665 | 0.89 | ULK1 (0.50) | ULK1PDK1ULK2EGFRPDPK1 | |
| SCHEMBL3712502 | 0.87 | EGFR (0.44) | ULK1PDK1ULK2EGFRITK | |
| SCHEMBL3714738 | 0.87 | EGFR (0.53) | EGFRAURKAITKJAK3BTK | |
| SCHEMBL3720749 | 0.83 | CCNT1 (0.51) | EGFRCDK2METALKITK | |
| SCHEMBL3715958 | 0.81 | MAPK9 (0.46) | EGFRALK | |
| SCHEMBL3721800 | 0.81 | SYK (0.46) | EGFRCDK2ITKJAK3BTK | |
| SCHEMBL914664 | 0.81 | ULK1 (0.61) | ULK1PDK1ULK2EGFRPDPK1 | |
| SCHEMBL913729 | 0.79 | ULK1 (0.59) | ULK1PDK1ULK2EGFRPDPK1 | |
| SCHEMBL22261265 | 0.78 | JAK3 (0.58) | CDK2TYK2ALKSTK17AJAK3 | |
| SCHEMBL913548 | 0.78 | STAT6 (0.67) | ULK1PDK1ULK2EGFRTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |