Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.53 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720749 | 0.88 | CCNT1 (0.51) | EGFRITKBTKJAK3MAPK8 | |
| SCHEMBL3713197 | 0.88 | MAP3K5 (0.50) | EGFRMAP3K5ITKBTKJAK3 | |
| SCHEMBL3721800 | 0.88 | SYK (0.46) | EGFRITKBTKJAK3MAPK8 | |
| SCHEMBL3722239 | 0.87 | ULK1 (0.50) | EGFRITKBTKJAK3AURKA | |
| SCHEMBL3712339 | 0.86 | MAPK9 (0.42) | EGFRJAK3MAPK8MAPK9JAK2 | |
| SCHEMBL3715143 | 0.83 | MAP3K5 (0.51) | EGFRMAP3K5ITKBTKJAK3 | |
| SCHEMBL913868 | 0.83 | MAP3K5 (0.53) | EGFRMAP3K5ITKBTKJAK3 | |
| SCHEMBL3712502 | 0.83 | EGFR (0.44) | EGFRITKBTKJAK3MAPK8 | |
| SCHEMBL3714460 | 0.82 | JAK3 (0.52) | EGFRMAP3K5BTKJAK3JAK2 | |
| SCHEMBL3712392 | 0.82 | MAPK8 (0.45) | EGFRITKBTKJAK3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |