Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.81 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297280 | 0.95 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL296879 | 0.93 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL12621388 | 0.92 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL297387 | 0.91 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL1942703 | 0.90 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| Lotamilast SCHEMBL369445 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL1942230 | 0.90 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| Lotamilast SCHEMBL29373383 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL296279 | 0.90 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL296765 | 0.90 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513269-B2 | Preparation for external use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-20 | — | — | US | disclosed |
| EP-2202229-B1 | NOVEL PREPARATION FOR EXTERNAL USE | EISAI R&D MAN CO LTD (JP) | 2012-03-14 | — | — | EP | disclosed |
| US-7939540-B2 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-10 | — | — | US | disclosed |
| US-20110021545-A1 | NOVEL PREPARATION FOR EXTERNAL USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-01-27 | — | — | US | disclosed |
| EP-1992622-A1 | 4-(3-BENZOYLAMINOPHENYL)-6,7-DIMETHOXY-2- METHYLAMINOQUINAZOLINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2008-11-19 | — | — | EP | disclosed |
| US-20070299094-A1 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | EISAI R&D MANAGEMENT CO., LTD. | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299094-A1 | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives | ITCH, HRH4, HRH1 | PDE4A 1280/4885PDE4B 1378/4885PDE4C 2057/4885 |
| US-20110021545-A1 | NOVEL PREPARATION FOR EXTERNAL USE | SLC26A4, SLC6A15, SLC6A19 | PDE4A 3486/4885PDE4B 3375/4885PDE4C 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.