Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27483882 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL27731212 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL5363705 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL27710812 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL27485266 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL3712402 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL688161 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL10408929 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL371304 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL27731207 | 1.00 | TSHR (0.90) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112098444-B | Gamma-HNIW crystal form standard substance crystal form purity value determination method | 西安近代化学研究所 | 2022-10-25 | — | — | CN | claimed |
| CN-112067641-B | Method for determining crystal form purity of alpha-HMX crystal form standard substance | 西安近代化学研究所 | 2022-10-25 | — | — | CN | claimed |
| CN-112098623-B | Method for determining crystal form purity value of alpha-HNIW crystal form standard substance | 西安近代化学研究所 | 2022-10-25 | — | — | CN | claimed |
| CN-107627527-A | The preparation method of copolymerized polymer foam with hydrophilic units | 中国科学院长春应用化学研究所 | 2018-01-26 | — | — | CN | claimed |
| US-20170157056-A9 | ORAL DOSAGE FORMS OF METHYL HYDROGEN FUMARATE AND PRODRUGS THEREOF | XENOPORT, INC. (US) | 2017-06-08 | — | — | US | claimed |
| US-20160113879-A1 | ORAL DOSAGE FORMS OF METHYL HYDROGEN FUMARATE AND PRODRUGS THEREOF | XENOPORT, INC. (US) | 2016-04-28 | — | — | US | claimed |
| US-20140348914-A9 | Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof | XENOPORT, INC. (US) | 2014-11-27 | — | — | US | claimed |
| US-20140348915-A9 | Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof | XENOPORT, INC. (US) | 2014-11-27 | — | — | US | claimed |
| US-20140065211-A1 | Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof | XENOPORT, INC. (US) | 2014-03-06 | — | — | US | claimed |
| US-20140056978-A1 | Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof | XENOPORT, INC. (US) | 2014-02-27 | — | — | US | claimed |
| US-20070072910-A1 | Compositions and methods for lowering plasma concentrations of low density lipoproteins in humans | NEXGEN PHARMA, INC. | 2007-03-29 | — | — | US | claimed |
| JP-62045561-A | — | — | None | — | — | JP | disclosed |
| JP-63014757-A | — | — | None | — | — | JP | disclosed |
| CN-117813313-A | Binding hepcidin mimetics | 领导医疗有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117480176-A | Hepcidin mimetics for the treatment of hereditary hemochromatosis | 领导医疗有限公司 | 2024-01-30 | — | — | CN | disclosed |
| EP-0974356-A1 | Tablets comprising a combination of metformin and glibenclamide | LIPHA (FR) | 2000-01-26 | — | — | EP | disclosed |
| US-5965553-A | Squalene synthetase inhibitors | PFIZER INC. (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0814080-A1 | Squalene synthetase inhibitors | PFIZER INC. (US) | 1997-12-29 | — | — | EP | disclosed |
| JP-S6314757-A | NOVEL DIOL BISALKENYL FUMARATE | NIPPON OIL & FATS CO LTD | 1988-01-21 | — | — | JP | disclosed |
| JP-S6245561-A | NOVEL DIOL BISALKYL FUMARATE | NIPPON OIL & FATS CO LTD | 1987-02-27 | — | — | JP | disclosed |