Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.90 |
| ▸ | TP53 | P04637 | 1/20 | 0.90 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.90 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.90 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27483882 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27731212 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5363705 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL371303 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL27710812 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27485266 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL3712402 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL10408929 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL371304 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL27731207 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119971780-A | Porous graphene composite membrane material modified by molecular engineering technology and preparation and application thereof | 华中科技大学 | 2025-05-13 | — | — | CN | claimed |
| CN-118949709-A | Composite nanofiltration membrane, preparation method and application thereof in phosphoric acid purification | 华中科技大学 | 2024-11-15 | — | — | CN | claimed |
| CN-114702659-A | Rosin-based defoaming agent for cleaning electronic devices and preparation method thereof | 江苏斯德瑞克化工有限公司 | 2022-07-05 | — | — | CN | claimed |
| EP-2493811-B1 | Method for sidewall functionalization of carbon nanotubes | FUTURE CARBON GMBH (DE) | 2018-01-17 | — | — | EP | claimed |
| US-8648167-B1 | Polymer scaffold degradation control via chemical control | STC UNM (US) | 2014-02-11 | — | — | US | claimed |
| EP-1488846-B1 | Composite semipermeable membrane, and production process thereof | TORAY INDUSTRIES (JP) | 2013-03-13 | — | — | EP | claimed |
| US-7279097-B2 | Composite semipermeable membrane, and production process thereof | TORAY INDUSTRIES, INC. (JP) | 2007-10-09 | — | — | US | claimed |
| US-20040256309-A1 | Composite semipermeable membrane, and production process thereof | TORAY INDUSTRIES, INC. (JP) | 2004-12-23 | — | — | US | claimed |
| EP-1488846-A1 | Composite semipermeable membrane, and production process thereof | TORAY INDUSTRIES, INC. (JP) | 2004-12-22 | — | — | EP | claimed |
| EP-0975599-A1 | SUBTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 2000-02-02 | — | — | EP | claimed |
| EP-0971898-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042674-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 1998-10-01 | — | — | WO | claimed |
| WO-1998042675-A1 | SUBSTITUTED ISOQUINOLINES AS ULTRA SHORT ACTING NEUROMUSCULAR BLOCKERS | GLAXO GROUP LIMITED (GB) | 1998-10-01 | — | — | WO | claimed |
| EP-0431124-B1 | NEW PLASTICS BASED ON FATTY ACIDS | FRISCHE GMBH (DE) | 1996-05-22 | — | — | EP | claimed |
| EP-0438579-B1 | NEW MONOMERIC UNITS OBTAINED FROM HYDROXY FATTY ACIDS, FOR MANUFACTURING PLASTICS | FRISCHE GMBH (DE) | 1995-10-25 | — | — | EP | claimed |
| US-5312889-A | Hydroxyfatty-acid-based monomers for producing plastics | BATTELLE-INSTITUT E.V. (DE) | 1994-05-17 | — | — | US | claimed |
| US-3971746-A | Synthetic polyisoprene rubber latex | KURARAY CO., LTD. (JA) | 1976-07-27 | — | — | US | claimed |
| WO-2025109900-A1 | METHOD FOR MANUFACTURING CIRCUIT BOARD | 株式会社有沢製作所 | 2025-05-30 | — | — | WO | disclosed |
| US-4086209-A | Novel nitrogen-containing aromatic polymers and process for their preparation | TEIJIN LIMITED (JA) | 1978-04-25 | — | — | US | disclosed |
| US-3971746-A | Synthetic polyisoprene rubber latex | KURARAY CO., LTD. (JA) | 1976-07-27 | — | — | US | disclosed |