Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448228 | 0.85 | TPMT (0.54) | TPMTRAB9AHCAR1 | |
| SCHEMBL4361178 | 0.85 | CES2 (0.56) | CES2CES1MEN1KMT2ARAB9A | |
| SCHEMBL12780435 | 0.82 | TAS1R3 (0.43) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1852011 | 0.82 | GSK3B (0.52) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL30512212 | 0.82 | TAS1R3 (0.43) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3147239 | 0.81 | MEN1 (0.42) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6175642 | 0.78 | TPMT (0.64) | TPMTRAB9AHCAR1 | |
| SCHEMBL6175693 | 0.78 | HCAR1 (0.55) | CES2CES1TPMTHCAR1 | |
| SCHEMBL5223999 | 0.77 | CES2 (0.46) | CES2CES1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL572200 | 0.77 | TPMT (0.70) | CES2CES1TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |