Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230726 | 0.85 | P2RX7 (0.46) | P2RX7POLBGAAPARP1PARP2 | |
| SCHEMBL28356118 | 0.81 | POLB (0.41) | P2RX7POLBGAAPARP1PARP2 | |
| SCHEMBL3073137 | 0.81 | POLB (0.41) | P2RX7POLBGAAPARP1PARP2 | |
| SCHEMBL20522823 | 0.81 | POLB (0.41) | P2RX7POLBGAAPARP1PARP2 | |
| SCHEMBL30237112 | 0.78 | IL4I1 (0.36) | P2RX7PARP1 | |
| SCHEMBL3069589 | 0.77 | EPHX1 (0.47) | P2RX7POLBGAAKMT2AALDH1A1 | |
| SCHEMBL1583619 | 0.77 | SLC18A3 (0.39) | P2RX7TSHRSMN1; SMN2 | |
| SCHEMBL21192934 | 0.75 | KDM5A (0.40) | P2RX7POLBGAANPC1RAB9A | |
| SCHEMBL21192936 | 0.75 | KDM5A (0.40) | P2RX7POLBGAANPC1RAB9A | |
| SCHEMBL21193141 | 0.75 | KDM5A (0.40) | P2RX7POLBGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063244-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-05-22 | — | — | WO | disclosed |