Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797332 | 0.86 | GRM5 (0.47) | GRM5 | |
| SCHEMBL3788618 | 0.85 | SNCA (0.38) | GRM5FFAR1 | |
| SCHEMBL3788621 | 0.85 | APP (0.40) | GRM5 | |
| SCHEMBL3790314 | 0.81 | LPL (0.46) | GRM5CHRNB2CHRNA4CYP2A6CYP2C9 | |
| SCHEMBL4078174 | 0.79 | MAPT (0.36) | CHRNB2CHRNA4CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL3721364 | 0.78 | FFAR1 (0.40) | GRM5FFAR1CYP1A2 | |
| SCHEMBL13188238 | 0.78 | CYP2A6 (0.46) | CYP2A6CYP2C9CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL3786338 | 0.77 | GRM5 (0.37) | GRM5CYP1A2 | |
| SCHEMBL4264297 | 0.74 | SNCA (0.44) | — | |
| SCHEMBL13907278 | 0.74 | CYP2A6 (0.62) | GRM5CHRNB2CHRNA4CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |