Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715755 | 0.85 | GSK3B (0.32) | GSK3B | |
| SCHEMBL31177281 | 0.85 | LRRK2 (0.40) | LRRK2GSK3BCDK1 | |
| SCHEMBL21087557 | 0.79 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL3713447 | 0.78 | LRRK2 (0.38) | LRRK2 | |
| SCHEMBL31177303 | 0.75 | DUT (0.42) | LRRK2 | |
| SCHEMBL21087554 | 0.74 | LRRK2 (0.40) | LRRK2 | |
| SCHEMBL3712175 | 0.74 | PAK1 (0.35) | GSK3BCDK1PAK1 | |
| SCHEMBL3713884 | 0.72 | CDK4 (0.48) | LRRK2CDK1 | |
| SCHEMBL1284361 | 0.72 | TBK1 (0.40) | LRRK2 | |
| SCHEMBL22518612 | 0.72 | LRRK2 (0.52) | LRRK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |