Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | SIK1 | P57059 | 1/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.32 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CCND1 | P24385 | 3/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845067 | 0.84 | RPS6KA3 (0.36) | RPS6KA3STAT6PTK2KMT2A | |
| SCHEMBL4187055 | 0.83 | GLO1 (0.41) | CDK4CCND1KMT2A | |
| SCHEMBL28793690 | 0.81 | RPS6KA3 (0.33) | RPS6KA3STAT6PTK2KMT2A | |
| SCHEMBL3712173 | 0.78 | LMNA (0.49) | RPS6KA3STAT6JAK2JAK3 | |
| SCHEMBL17066933 | 0.77 | JAK2 (0.33) | RPS6KA3CDK4CCND1STAT6GSK3B | |
| SCHEMBL30881456 | 0.77 | JAK2 (0.33) | RPS6KA3CDK4CCND1STAT6GSK3B | |
| SCHEMBL24150591 | 0.76 | KMO (0.50) | JAK2 | |
| SCHEMBL30019214 | 0.76 | P2RX7 (0.41) | RPS6KA3STAT6GSK3BCDK1AURKA | |
| SCHEMBL3713449 | 0.74 | LRRK2 (0.40) | PAK1GSK3BCDK1 | |
| SCHEMBL30019422 | 0.74 | STAT6 (0.41) | RPS6KA3STAT6FYNSRCPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |