Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503525 | 0.82 | EP300 (0.38) | METMEN1KMT2A | |
| SCHEMBL359630 | 0.80 | MET (0.42) | METMEN1KMT2A | |
| SCHEMBL359649 | 0.79 | GFER (0.33) | METKMT2AMAP4K4 | |
| SCHEMBL369021 | 0.79 | MET (0.39) | METGRM2 | |
| SCHEMBL14915939 | 0.78 | KDM5A (0.33) | MET | |
| SCHEMBL2343070 | 0.78 | ALDH1A1 (0.41) | MET | |
| SCHEMBL14916044 | 0.78 | MEN1 (0.36) | METMEN1KMT2AGRM2 | |
| SCHEMBL10283525 | 0.77 | RAB9A (0.37) | MEN1KMT2A | |
| SCHEMBL164181 | 0.76 | MET (0.53) | MET | |
| SCHEMBL173996 | 0.75 | CYP2C9 (0.37) | RIPK2MEN1KMT2AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |