Sugi Predict

Sugi Predict / Compounds / SCHEMBL3713718

SCHEMBL3713718

SCHEMBL3713718

O=C(O)Cc1cccc2nccnc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.50
▸ MAPT P10636 3/20 0.50
▸ CYP1A2 P05177 2/20 0.50
▸ MAPK8 P45983 3/20 0.46
▸ MAPK9 P45984 3/20 0.46
▸ MAPK10 P53779 3/20 0.46
▸ AKR1B1 P15121 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.44
▸ MEN1 O00255 4/20 0.43
▸ KMT2A Q03164 4/20 0.43
▸ ALDH1A1 P00352 4/20 0.43
▸ USP2 O75604 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ DUSP3 P51452 1/20 0.40
▸ PTPN5 P54829 1/20 0.40
▸ PTPN11 Q06124 1/20 0.40
▸ CTDSP1 Q9GZU7 1/20 0.40
▸ THRB P10828 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29456254 0.84 MAPK8 (0.45) KDM4EMAPTCYP1A2MAPK8MAPK9
SCHEMBL6902980 0.84 MAPK8 (0.45) KDM4EMAPTCYP1A2MAPK8MAPK9
SCHEMBL9175645 0.81 CYP1A2 (0.50) KDM4EMAPTCYP1A2AKR1B1TDP1
SCHEMBL3720399 0.79 KDM4E (0.59) KDM4EMAPTCYP1A2MAPK8MAPK9
SCHEMBL30553881 0.79 KDM4E (0.59) KDM4EMAPTCYP1A2TDP1ALDH1A1
SCHEMBL3711541 0.79 KDM4E (0.59) KDM4EMAPTCYP1A2TDP1ALDH1A1
Hydrochloric Acid SCHEMBL3712126 0.77 KDM4E (0.57) KDM4EMAPTCYP1A2MAPK8MAPK9
SCHEMBL8596016 0.77 MAPT (0.48) KDM4EMAPTMAPK8MAPK9MAPK10
SCHEMBL3709497 0.77 MAPK8 (0.46) KDM4EMAPTMAPK8MAPK9MAPK10
SCHEMBL2291662 0.75 ALDH1A1 (0.56) KDM4EMAPTCYP1A2AKR1B1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220081427-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2022-03-17 — — US disclosed
US-20200277285-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2020-09-03 — — US disclosed
US-20200039972-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2020-02-06 — — US disclosed
US-20190194176-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2019-06-27 — — US disclosed
US-20180319780-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2018-11-08 — — US disclosed
US-20180037577-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2018-02-08 — — US disclosed
EP-2393806-B1 INHIBITORS OF JUN N-TERMINAL KINASE ELAN PHARM INC (US) 2017-10-25 — — EP disclosed
US-9796706-B2 Inhibitors of Jun N-terminal kinase IMAGO PHARMACEUTICALS, INC. (US) 2017-10-24 — — US disclosed
US-20170107209-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2017-04-20 — — US disclosed
US-20150259330-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2015-09-17 — — US disclosed
US-9073891-B2 Inhibitors of Jun N-terminal kinase IMAGO PHARMACEUTICALS, INC. (US) 2015-07-07 — — US disclosed
CN-101553491-B Quinoxaline derivative ASKA PHARM CO LTD 2013-05-29 — — CN disclosed
US-8450363-B2 Inhibitors of Jun N-terminal kinase ELAN PHARMACEUTICALS, INC. (US) 2013-05-28 — — US disclosed
US-20130072494-A1 INHIBITORS OF JUN N-TERMINAL KINASE ELAN PHARMACEUTICALS, INC. 2013-03-21 — — US disclosed
CN-102365277-A Inhibitors of jun n-terminal kinase ELAN PHARM INC 2012-02-29 — — CN disclosed
EP-2393806-A1 INHIBITORS OF JUN N-TERMINAL KINASE Elan Pharmaceuticals Inc. (US) 2011-12-14 — — EP disclosed
US-20100331335-A1 Inhibitors of Jun N-Terminal Kinase ELAN PHARMACETICALS, INC. 2010-12-30 — — US disclosed
WO-2010091310-A1 INHIBITORS OF JUN N-TERMINAL KINASE ELAN PHARMACEUTICALS, INC. (US) 2010-08-12 — — WO disclosed
CN-101553491-A Quinoxaline derivative ASKA PHARM CO LTD (JP) 2009-10-07 — — CN disclosed
WO-1998005651-A1 NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES WARNER-LAMBERT COMPANY (US) 1998-02-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200039972-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20190194176-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20150259330-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20170107209-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20180037577-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20130072494-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20220081427-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20200277285-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20180319780-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885
US-20100331335-A1 Inhibitors of Jun N-Terminal Kinase CHUK, MAPK6, MAPK3 KDM4E 1237/4885MAPT 51/4885CYP1A2 3825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.