Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456254 | 1.00 | MAPK8 (0.45) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL3713718 | 0.84 | KDM4E (0.50) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL3783847 | 0.79 | GLS (0.49) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL9181528 | 0.79 | PARP1 (0.57) | KDM4EMAPTALDH1A1HDAC6HSD17B10 | |
| SCHEMBL8637800 | 0.76 | MAPK8 (0.37) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL10809062 | 0.76 | ALDH1A1 (0.50) | KDM4EMAPTKMT2AALDH1A1NPSR1 | |
| SCHEMBL25846851 | 0.76 | LOXL2 (0.52) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL8596016 | 0.76 | MAPT (0.48) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL3709497 | 0.75 | MAPK8 (0.46) | MAPK8MAPK9MAPK10KDM4EMAPT | |
| SCHEMBL3329530 | 0.74 | MTNR1B (0.44) | MAPK8MAPK9MAPK10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102143961-A | Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity | NEURAXON INC | 2011-08-03 | — | — | CN | claimed |
| CN-101679397-A | Quinolone and tetrahydroquinoline having NOS inhibitory activity and related compounds | NEURAXON INC | 2010-03-24 | — | — | CN | disclosed |
| WO-2004039371-A2 | COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF NEUROPATHIC PAIN | PHARMACIA CORPORATION (US) | 2004-05-13 | — | — | WO | disclosed |