Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491515 | 0.87 | DHFR (0.46) | DHFRTYMPCYP1A2DNMT1KDM4E | |
| SCHEMBL2495765 | 0.85 | HTR1A (0.35) | MAPTNPC1MEN1RAB9AKMT2A | |
| SCHEMBL3153748 | 0.81 | AKR1C3 (0.49) | AKR1C3AKR1C2CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL30002959 | 0.81 | AKR1C3 (0.49) | AKR1C3AKR1C2CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2030385 | 0.80 | CYP17A1 (0.43) | DHFRTYMPCYP1A2ADORA2AKDM4E | |
| SCHEMBL22978397 | 0.80 | NPC1 (0.43) | DHFRAKR1C3AKR1C2TYMPCYP1A1 | |
| SCHEMBL28779511 | 0.79 | AKR1C3 (0.40) | DHFRAKR1C3AKR1C2TYMPCYP1A1 | |
| SCHEMBL28232750 | 0.79 | DHFR (0.44) | DHFRAKR1C3AKR1C2TYMPCYP1A1 | |
| SCHEMBL29104508 | 0.79 | AKR1C3 (0.47) | AKR1C3AKR1C2CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL29165700 | 0.73 | DHFR (0.39) | DHFRAKR1C3AKR1C2CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398815-A2 | SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS | Chemgenes Corporation (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010096201-A2 | SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS | CHEMGENES CORPORATION (US) | 2010-08-26 | — | — | WO | disclosed |