Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805901 | 0.94 | ROCK2 (0.58) | ROCK2ROCK1AKT1 | |
| SCHEMBL3803880 | 0.82 | ROCK2 (0.39) | ROCK2ROCK1AKT1PIM1PIM3 | |
| SCHEMBL3810004 | 0.81 | GSK3B (0.38) | ROCK2ROCK1AKT1PIM1PIM3 | |
| SCHEMBL3717171 | 0.78 | ROCK2 (0.41) | ROCK2ROCK1PIM1PIM3 | |
| SCHEMBL3809961 | 0.78 | CDC7 (0.35) | ROCK2CLK4HRH3PIM1 | |
| SCHEMBL3808241 | 0.76 | AKT2 (0.43) | ROCK2ROCK1FLT3AKT1PIM1 | |
| SCHEMBL3719906 | 0.74 | ROCK2 (0.45) | ROCK2ROCK1AKT1PIM1PIM3 | |
| SCHEMBL3813838 | 0.73 | SLC2A1 (0.43) | ROCK2ROCK1 | |
| SCHEMBL3723622 | 0.73 | ROCK2 (0.42) | ROCK2ROCK1CLK4HRH3PIM1 | |
| SCHEMBL3805844 | 0.72 | KDR (0.48) | ROCK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |