Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806598 | 0.83 | AKT2 (0.37) | ROCK2ROCK1AKT1AKT2PIM1 | |
| SCHEMBL3804940 | 0.77 | SIGMAR1 (0.37) | ROCK2ROCK1 | |
| SCHEMBL3805901 | 0.75 | ROCK2 (0.58) | ROCK2ROCK1AKT1CDC42BPA | |
| SCHEMBL3713952 | 0.74 | ROCK2 (0.51) | ROCK2ROCK1AKT1PIM1PIM3 | |
| SCHEMBL3813989 | 0.74 | CHEK1 (0.40) | ROCK2AURKAAURKBROCK1 | |
| SCHEMBL3722649 | 0.72 | HTR7 (0.43) | HTR1AHTR7AURKAAURKBROCK1 | |
| SCHEMBL3808241 | 0.67 | AKT2 (0.43) | ROCK2ROCK1AKT1AKT2PIM1 | |
| SCHEMBL3716570 | 0.67 | AKT2 (0.46) | ROCK2ROCK1AKT1AKT2PIM1 | |
| SCHEMBL1404499 | 0.67 | AKT1 (0.46) | ROCK2ROCK1AKT1AKT2PIM1 | |
| SCHEMBL3717171 | 0.65 | ROCK2 (0.41) | ROCK2ROCK1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |