Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25620321 | 0.86 | ENPP2 (0.52) | ENPP2DRD2DRD1TAAR1CTBP2 | |
| SCHEMBL6473210 | 0.80 | HTR3E (0.52) | TAAR1CTBP2CYP3A4LMNAALDH1A1 | |
| SCHEMBL28353912 | 0.78 | TAAR1 (0.50) | TAAR1CTBP2 | |
| SCHEMBL17276661 | 0.78 | TAAR1 (0.46) | TAAR1CYP3A4CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL7651106 | 0.78 | ENPP2 (0.52) | ENPP2DRD2DRD1TAAR1CYP3A4 | |
| SCHEMBL4327800 | 0.77 | AGXT (0.46) | KMT2A | |
| SCHEMBL350297 | 0.77 | ENPP2 (0.56) | ENPP2DRD2DRD1TAAR1CTBP2 | |
| SCHEMBL265957 | 0.76 | MAOB (0.59) | CTBP2KMT2AALDH1A1CA2 | |
| SCHEMBL5665711 | 0.76 | MAOB (0.59) | CTBP2KMT2AALDH1A1CA2 | |
| SCHEMBL1060278 | 0.76 | MAOB (0.59) | CTBP2KMT2AALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |