Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713714 | 0.89 | RXFP1 (0.43) | KDM4EGAAPKMTYRO3MERTK | |
| SCHEMBL3714672 | 0.83 | KMT2A (0.44) | KDM4EGAATYRO3MERTKGAS6 | |
| SCHEMBL3713336 | 0.80 | ESR1 (0.41) | KDM4ESMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL3711572 | 0.79 | MAPT (0.47) | KDM4EGAAPKMSMN1; SMN2MAPT | |
| SCHEMBL3711025 | 0.78 | ESR1 (0.39) | KDM4EGAAPKMSMN1; SMN2MAPT | |
| SCHEMBL3710281 | 0.77 | GAA (0.43) | KDM4EGAASMN1; SMN2MAPTHPGD | |
| SCHEMBL3718647 | 0.77 | HDAC3 (0.39) | TYRO3MERTKGAS6RAB9AMAPK1 | |
| SCHEMBL3713374 | 0.75 | ESR1 (0.46) | KDM4ESMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL3713822 | 0.73 | TSHR (0.54) | KDM4EGAASMN1; SMN2MAPTHPGD | |
| SCHEMBL3712970 | 0.72 | ALDH1A1 (0.45) | KDM4EGAAMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |