Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188415 | 0.83 | KMT2A (0.49) | KMT2AMEN1RAB9ALMNAMAPT | |
| SCHEMBL3714487 | 0.83 | KCNH3 (0.40) | KMT2AMEN1RAB9ATSHRMAPT | |
| SCHEMBL3714237 | 0.83 | KDM4E (0.43) | KMT2AMEN1RAB9ALMNATSHR | |
| SCHEMBL3710281 | 0.82 | GAA (0.43) | MAPTHPGDALDH1A1KDM4EGAA | |
| SCHEMBL3713714 | 0.82 | RXFP1 (0.43) | KMT2AMEN1RAB9ALMNAMAPT | |
| SCHEMBL3713458 | 0.81 | GRM5 (0.45) | LMNATSHRMAPTHPGDALDH1A1 | |
| SCHEMBL3713446 | 0.81 | ALDH1A1 (0.47) | KMT2AMEN1RAB9ALMNATSHR | |
| SCHEMBL3715992 | 0.70 | MAPK1 (0.43) | RAB9ALMNATSHRMAPTL3MBTL1 | |
| SCHEMBL3711316 | 0.68 | ALK (0.40) | ACACBL3MBTL1HRH3 | |
| SCHEMBL3709302 | 0.68 | BCHE (0.44) | KMT2AMEN1RAB9ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |