Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188594 | 0.94 | HRH3 (0.54) | HRH3AURKAJAK2PRMT6ATM | |
| SCHEMBL3714557 | 0.84 | HDAC3 (0.47) | MMP2MMP8MMP13DYRK1A | |
| SCHEMBL3713224 | 0.82 | JAK2 (0.41) | HRH3AURKAJAK2PRMT6MMP2 | |
| SCHEMBL3713512 | 0.81 | TBK1 (0.43) | MMP2MMP8MMP13DYRK1A | |
| SCHEMBL3710203 | 0.80 | JAK2 (0.44) | HRH3AURKAJAK2ATML3MBTL1 | |
| SCHEMBL13188416 | 0.76 | HRH3 (0.48) | HRH3AURKAJAK2PRMT6ATM | |
| SCHEMBL3718099 | 0.76 | MMP2 (0.44) | MMP2MMP8MMP13 | |
| SCHEMBL15919371 | 0.76 | ACP1 (0.46) | HRH3JAK2DYRK1A | |
| SCHEMBL3713020 | 0.76 | PIK3CD (0.41) | MMP2MMP8MMP13DYRK1A | |
| SCHEMBL3714355 | 0.74 | MMP2 (0.42) | MMP2MMP8MMP13DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |