Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714548 | 1.00 | ATM (0.50) | ATMTDP1TTRAPPALDH1A1 | |
| SCHEMBL28537382 | 0.86 | THRB (0.42) | ATMTDP1TTRALDH1A1HTT | |
| SCHEMBL11155059 | 0.84 | NPSR1 (0.54) | ATMTDP1TTRALDH1A1HTT | |
| SCHEMBL10779478 | 0.82 | ATM (0.45) | ATMTDP1TTRAPPALDH1A1 | |
| SCHEMBL10779486 | 0.82 | ATM (0.45) | ATMTDP1TTRAPPALDH1A1 | |
| SCHEMBL12724984 | 0.82 | TDP1 (0.58) | ATMTDP1TTRALDH1A1HTT | |
| SCHEMBL11852183 | 0.81 | MAPK1 (0.50) | TDP1TTRALDH1A1HTTNPC1 | |
| SCHEMBL11852169 | 0.81 | MAPK1 (0.50) | TDP1TTRALDH1A1HTTNPC1 | |
| SCHEMBL11149736 | 0.80 | ATM (0.43) | ATMTDP1TTRAPPALDH1A1 | |
| SCHEMBL142930 | 0.80 | THRB (0.44) | ATMTDP1TTRALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0032620-B2 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | claimed |
| WO-2010106016-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-09-23 | — | — | WO | disclosed |
| WO-2004073705-A1 | 1-PHENYL-2- MONOALKYL CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
| EP-0032620-B2 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0135249-B1 | STYRENE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1986-11-12 | — | — | EP | disclosed |
| US-4557871-A | Novel styrene derivatives of the general formula | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1985-12-10 | — | — | US | disclosed |
| EP-0135249-A1 | Styrene derivatives | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1985-03-27 | — | — | EP | disclosed |
| EP-0032620-B1 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4398035-A | INTERMEDIATE FOR FLURBIPROFEN | THE UPJOHN COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4398035-A | INTERMEDIATE FOR FLURBIPROFEN | THE UPJOHN COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4324904-A | COMPOUND USEFUL IN MAKING FLURBIPROFEN | THE UPJOHN COMPANY (US) | 1982-04-13 | — | — | US | disclosed |
| US-4324904-A | COMPOUND USEFUL IN MAKING FLURBIPROFEN | THE UPJOHN COMPANY (US) | 1982-04-13 | — | — | US | disclosed |
| EP-0032620-A1 | Process for preparing therapeutic 2-arylpropionic acids and esters, and novel arylmethylmalonate esters | THE UPJOHN COMPANY (US) | 1981-07-29 | — | — | EP | disclosed |
| US-4266069-A | Processes for the preparation of hydratropic acids and esters | THE UPJOHN COMPANY (US) | 1981-05-05 | — | — | US | disclosed |
| US-4266069-A | Processes for the preparation of hydratropic acids and esters | THE UPJOHN COMPANY (US) | 1981-05-05 | — | — | US | disclosed |