SCHEMBL3714746

SCHEMBL3714746

Cc1ccnc(CNc2cccc3cnccc23)c1-c1ccc(F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.42
CYP17A1 P05093 1/20 0.39
CYP1A2 P05177 1/20 0.39
ROS1 P08922 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
TRPV1 Q8NER1 4/20 0.38
ALDH1A1 P00352 6/20 0.38
MAPT P10636 4/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 2/20 0.38
THRB P10828 1/20 0.38
HTT P42858 1/20 0.38
BLM P54132 1/20 0.38
GPBAR1 Q8TDU6 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
ROCK2 O75116 1/20 0.36
CCR2 P41597 1/20 0.36
ROCK1 Q13464 1/20 0.36
CYP19A1 P11511 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3720423 0.81 ALDH1A1 (0.45) DHFRHDAC6ALDH1A1MAPTKMT2A
SCHEMBL3717729 0.74 HDAC6 (0.40) DHFRHDAC6TRPV1ALDH1A1MAPT
SCHEMBL3721720 0.68 GPBAR1 (0.54) ROS1KMT2AMEN1GPBAR1CYP19A1
SCHEMBL21187476 0.67 HSD11B1 (0.43) CYP17A1CYP1A2ROS1
SCHEMBL3714728 0.66 GPBAR1 (0.54) GPBAR1CYP19A1CYP11B1CYP11B2
SCHEMBL21187438 0.66 HSD11B1 (0.42) CYP17A1CYP1A2ROS1
SCHEMBL3716494 0.65 GPBAR1 (0.57) GPBAR1CYP19A1CYP11B1CYP11B2
SCHEMBL3713000 0.64 GPBAR1 (0.45) KMT2AMEN1GPBAR1CYP19A1CYP11B1
SCHEMBL11142216 0.64 ALDH1A1 (0.53) DHFRCYP1A2HDAC6TRPV1ALDH1A1
SCHEMBL24522617 0.63 HDAC6 (0.73) HDAC6TRPV1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010117090-A1 NOVEL ISOQUINOLINYLOXYMETHYL HETEROARYL DERIVATIVES BANYU PHARMACEUTICAL CO.,LTD. (JP) 2010-10-14 WO claimed
WO-2014133414-A2 HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF АЛЛА ХЕМ ЛЛС (US) 2014-09-04 WO disclosed
WO-2010117090-A1 NOVEL ISOQUINOLINYLOXYMETHYL HETEROARYL DERIVATIVES BANYU PHARMACEUTICAL CO.,LTD. (JP) 2010-10-14 WO disclosed
WO-2010117090-A1 NOVEL ISOQUINOLINYLOXYMETHYL HETEROARYL DERIVATIVES BANYU PHARMACEUTICAL CO.,LTD. (JP) 2010-10-14 WO disclosed