Sugi Predict

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Probicromil

Probicromil

SCHEMBL371493

CCCc1c2oc(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)oc12

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PDE5A O76074 4/20 0.55
▸ ABCB11 O95342 1/20 0.54
▸ CYSLTR2 Q9NS75 2/20 0.50
▸ CYSLTR1 Q9Y271 2/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ TBXAS1 P24557 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ GPR35 Q9HC97 11/20 0.49
▸ KDM4E B2RXH2 2/20 0.44
▸ USP2 O75604 1/20 0.44
▸ CSNK2A2 P19784 1/20 0.44
▸ PTGS1 P23219 1/20 0.44
▸ CSNK2B P67870 1/20 0.44
▸ CSNK2A1 P68400 1/20 0.44
▸ CSNK2A3 Q8NEV1 1/20 0.44
▸ AKR1B1 P15121 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Probicromil SCHEMBL11378747 0.98 PDE5A (0.54) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10506749 0.93 PDE5A (0.50) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10507005 0.91 PDE5A (0.53) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10507452 0.89 PDE5A (0.50) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL11066769 0.89 ABCB11 (0.49) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10504791 0.87 PDE5A (0.48) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10506670 0.87 PDE5A (0.49) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10505756 0.86 PDE5A (0.48) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10505747 0.86 PDE5A (0.48) PDE5AABCB11CYSLTR2CYSLTR1MEN1
SCHEMBL10507264 0.86 PDE5A (0.43) PDE5AABCB11CYSLTR2CYSLTR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 207 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11136342-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2021-10-05 — — US claimed
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME ACORDA THERAPEUTICS, INC. 2020-05-21 — — US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
CN-101919822-B Tablet with improved combination properties and preparation method thereof ZHONG SHUGUANG 2013-10-23 — — CN claimed
US-20110212927-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME NEUROGESX, INC. (US) 2011-09-01 — — US claimed
CN-102149282-A Carbonate prodrugs and methods of using the same NEUROGESX INC 2011-08-10 — — CN claimed
EP-2291084-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME Neurogesx, Inc. (US) 2011-03-09 — — EP claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
WO-2009143297-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME NEUROGESX, INC. (US) 2009-11-26 — — WO claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
US-4293541-A SALTS OF 2,8-DICARBOXY-4,6-DIOXO-10-PROPYL-4H, 6H-BENZO/1,2-B:4,5-B'/DIPYRAN FISONS LIMITED (GB) 1981-10-06 — — US claimed
US-4239748-A Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever FISONS LIMITED (GB) 1980-12-16 — — US claimed
EP-4522200-A2 RECOMBINANT NEPROSIN POLYPEPTIDES AND METHODS OF EXPRESSION Codexis, Inc. (US) 2025-03-19 — — EP disclosed
CN-119325388-A Recombinant neprosin polypeptides and expression methods 科德克希思公司 2025-01-17 — — CN disclosed
US-4239748-A Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever FISONS LIMITED (GB) 1980-12-16 — — US disclosed
US-4239748-A Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever FISONS LIMITED (GB) 1980-12-16 — — US disclosed
US-4239748-A Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever FISONS LIMITED (GB) 1980-12-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212927-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME CA6, CA7, CA4 PDE5A 328/4885ABCB11 941/4885CYSLTR2 3273/4885
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME CA6, CA7, CA4 PDE5A 328/4885ABCB11 941/4885CYSLTR2 3273/4885
US-11136342-B2 Carbonate prodrugs and methods of using the same CA6, CA7, CA4 PDE5A 328/4885ABCB11 941/4885CYSLTR2 3273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.